Shigellahost: Pathogen interactions: Keeping bacteria in the loop

Cell–pathogen interactions (viruses and bacteria)

This was a diverse session reflecting the many different mechanisms utilized by viral and bacterial pathogens to modulate and affect host cell biology. The talks and the lively question and answer sessions that followed ranged from discussing the impact of pathogens on generating the optimal cellular milieu for replication and assembly to understanding the host cell antipathogenic response. Sco...

Chromosome Segregation: Keeping Kinetochores in the Loop

The Ndc80 complex is a key component of the kinetochore-microtubule interface. Two studies now demonstrate that a conserved loop region within the extended coiled-coil of Ndc80 plays an unexpected role in recruiting proteins to the kinetochore.

Keeping the Intelligent Environment Resident in the Loop

Recent technological advancements have increased the likelihood that smart home technologies will become part of our everyday environments. However, many of these technologies are brittle and do not adapt to the user’s wishes or changes in residents’ habits and lifestyle. Here we introduce CASAS, an adaptive smart home that utilizes machine learning techniques to discover patterns in user behav...

Bacteria Pathogen Virulence Primer

Semi-Automatic Index Tuning: Keeping DBAs in the Loop

To obtain good system performance, a DBA must choose a set of indices that is appropriate for the workload. The system can aid in this challenging task by providing recommendations for the index configuration. We propose a new index recommendation technique, termed semi-automatic tuning, that keeps the DBA “in the loop” by generating recommendations that use feedback about the DBA’s preferences...